Jeffrey N. Higaki: search on Z-Library

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1

Anti-Mcam Monoclonal Antibody PRX003 Inhibits the Unique Migratory Potential of Pathogenic IL-17–Producing T Cells

Flanagan, Kenneth, Tam, Stephen J., Li, Lauri, Dolan, Philip J., Barbour, Robin M., Higaki, Jeffrey N., Liu, Yue, Nijjar, Tarlochan, Skov, Michael, Zago, Wagner, Yednock, Ted A., Kinney, Gene F., Ness

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 127 KB

english, 2016

2

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Higaki, Jeffrey N, Chakrabartty, Avi, Galant, Natalie J, Hammerson, Bradley, Torres, Ronald, Salmans, Joshua, Barbour, Robin, Kinney, Gene G

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 263 KB

english, 2015

3

Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy

Galant, Natalie J., Westermark, Per, Higaki, Jeffrey N., Chakrabartty, Avijit

Journal:

Clinical Science

Year:

2017

Language:

english

File:

PDF, 398 KB

english, 2017

4

An expression system for trypsin

John R. Vasquez, Luke B. Evnin, Jeffrey N. Higaki, Charles S. Craik

Journal:

Journal of Cellular Biochemistry

Year:

1989

Language:

english

File:

PDF, 800 KB

english, 1989

5

The identification of neotrypsinogens in samples of bovine trypsinogen

Jeffrey N. Higaki, Albert Light

Journal:

Analytical Biochemistry

Year:

1985

Language:

english

File:

PDF, 1.32 MB

english, 1985

6

Pyrimidine-based inhibitors of CaMKIIδ

Babu Mavunkel, Yong-jin Xu, Bindu Goyal, Don Lim, Qing Lu, Zheng Chen, Dan-Xiong Wang, Jeffrey Higaki, Indrani Chakraborty, Albert Liclican, Steve Sideris, Maureen Laney, Ulrike Delling, Rosanne Catal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 183 KB

english, 2008

7

Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 3: Importance of the indole orientation

Qing Lu, Zheng Chen, John Perumattam, Dan-Xiong Wang, Weiling Liang, Yong-jin Xu, Steven Do, Llorente Bonaga, Jeffrey Higaki, Hanmin Dong, Albert Liclican, Steve Sideris, Maureen Laney, Sundeep Dugar,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

8

Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 2: SAR of the amine tether

Daniel E. Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Yong-jin Xu, Jeffrey Higaki, Hanmin Dong, Albert Liclican, Maureen Laney, Babu Mavunkel, Sundeep Dugar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

9

Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region

Daniel E. Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Yong-jin Xu, Albert Liclican, Jeffrey Higaki, Hanmin Dong, Maureen Laney, Babu Mavunkel, Sundeep Dugar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 205 KB

english, 2008

10

Inhibition of β-Amyloid Formation by Haloperidol: A Possible Mechanism for Reduced Frequency of Alzheimer's Disease Pathology in Schizophrenia

Jeffrey Higaki, Greer M. Murphy Jr., Barbara Cordell

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 500 KB

english, 1997

11

A Possible Role for Cathepsins D, E, and B in the Processing of β-amyloid Precursor Protein in Alzheimer's Disease

Elaine A. Mackay, Anne Ehrhard, Marc Moniatte, Chantal Guenet, Chantal Tardif, Celine Tarnus, Odile Sorokine, Blanche Heintzelmann, Carole Nay, Jean-Marc Remy, Jeffrey Higaki, Alain Van Dorsselaer, Jo

Journal:

Year:

1997

Language:

english

File:

PDF, 1.33 MB

english, 1997

12

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

Jeffrey Higaki, Diana Quon, Ziyang Zhong, Barbara Cordell

Journal:

Year:

1995

Language:

english

File:

PDF, 4.28 MB

english, 1995

13

Crystal structure of rat trypsin-S195C at −150 °C: Analysis of low activity of recombinant and semisynthetic thiol proteases

Marjorie E. Wilke, Jeffrey N. Higaki, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1.50 MB

english, 1991

14

Crystallographic analysis of trypsin-G226A: A specificity pocket mutant of rat trypsin with altered binding and catalysis

Marjorie E. Wilke, Jeffrey N. Higaki, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 867 KB

english, 1991

15

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

Hagg, Theo, Quon, Diana, Higaki, Jeffrey, Varon, Silvio

Journal:

Year:

1992

Language:

english

File:

PDF, 11.18 MB

english, 1992

16

Engineered metalloregulation in enzymes

Higaki, Jeffrey N., Fletterick, Robert J., Craik, Charles S.

Journal:

Trends in Biochemical Sciences

Year:

1992

Language:

english

File:

PDF, 591 KB

english, 1992

17

Crystal structures of two engineered thiol trypsins

McGrath, Mary E., Wilke, Marjorie E., Higaki, Jeffrey N., Craik, Charles S., Fletterick, Robert J.

Journal:

Year:

1989

Language:

english

File:

PDF, 3.11 MB

english, 1989

18

Introduction of a cysteine protease active site into trypsin

Higaki, Jeffrey N., Evnin, Luke B., Craik, Charles S.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.62 MB

english, 1989

19

A Combinatorial Approach to the Identification of Dipeptide Aldehyde Inhibitors of β-Amyloid Production

Higaki, Jeffrey N., Chakravarty, Sarvajit, Bryant, Carmen M., Cowart, Lisa R., Harden, Paul, Scardina, Jan Marian, Mavunkel, Babu, Luedtke, Gregory R., Cordell, Barbara

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 188 KB

english, 1999

20

Regulation of serine protease activity by an engineered metal switch

Higaki, Jeffrey N., Haymore, Barry L., Chen, Shell, Fletterick, Robert J., Craik, Charles S.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.18 MB

english, 1990

21

Detection of intermediate species in the refolding of bovine trypsinogen

Light, Albert, Higaki, Jeffrey N.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.61 MB

english, 1987

22

Amyloid Forming Proteases: Therapeutic Targets for Alzheimers Disease

Schimmoller, Frauke, Higaki, Jeffrey, Cordell, Barbara

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

23

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Fl

Journal:

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

24

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Galant, Natalie J., Bugyei-Twum, Antoinette, Rakhit, Rishi, Walsh, Patrick, Sharpe, Simon, Arslan, Pharhad Eli, Westermark, Per, Higaki, Jeffrey N., Torres, Ronald, Tapia, José, Chakrabartty, Avijit

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

25

DEVELOPING TARGETED MONOCLONAL ANTIBODY THERAPIES TO DETECT AND REVERSE CARDIAC AMYLOIDOSIS

Galant, Natalie J., Higaki, Jeffrey N., Chakrabartty, Avi

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

26

Erratum: Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Galant, Natalie J., Bugyei-Twum, Antoinette, Rakhit, Rishi, Walsh, Patrick, Sharpe, Simon, Arslan, Pharhad Eli, Westermark, Per, Higaki, Jeffrey N., Torres, Ronald, Tapia, José, Chakrabartty, Avijit

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 120 KB

english, 2016